|
rs741301
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The rs741301-G allele and the rs10255208-GG genotype, gene-environment interaction between rs741301 and alcohol drinking were all associated with increased DN risk.
|
31798690 |
2019 |
|
rs10255208
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs741301-G allele and the rs10255208-GG genotype, gene-environment interaction between rs741301 and alcohol drinking were all associated with increased DN risk.
|
31798690 |
2019 |
|
rs1345365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found that the others SNPs-rs1345365 and rs7782979 were not significantly associated with susceptibility to DN.
|
31798690 |
2019 |
|
rs7782979
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found that the others SNPs-rs1345365 and rs7782979 were not significantly associated with susceptibility to DN.
|
31798690 |
2019 |
|
rs2281999
|
|
|
0.010 |
GeneticVariation |
BEFREE |
RESULTS There were no significant differences in the distribution of allele or genotype frequencies in the five UNC13B SNP markers (rs13293564, rs17360668, rs10114937, rs661712, and rs2281999) between the DKD group and control group of patients with T2DM.
|
31713534 |
2019 |
|
rs11643718
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The results showed in this systematic review contribute to better understanding of the association between the Arg913Gln variation of SLC12A3 gene with the pathogenesis of diabetic nephropathy in individuals with T2DM and GS.
|
31660880 |
2019 |
|
rs1800775
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the A-allele of rs4783961 was significantly associated with a reduced T2D risk (odds ratio (OR), 0.82; 95% confidence interval (CI), 0.71‒0.96)), and the A-allele of rs1800775 was significantly related to a lowered DKD risk (OR, 0.78; 95% CI, 0.64‒0.96).
|
31597401 |
2019 |
|
rs4783961
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the A-allele of rs4783961 was significantly associated with a reduced T2D risk (odds ratio (OR), 0.82; 95% confidence interval (CI), 0.71‒0.96)), and the A-allele of rs1800775 was significantly related to a lowered DKD risk (OR, 0.78; 95% CI, 0.64‒0.96).
|
31597401 |
2019 |
|
rs55703767
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs55703767 minor allele (Asp326Tyr) is protective against several definitions of diabetic kidney disease, including albuminuria and ESKD, and demonstrated a significant association with GBM width; protective allele carriers had thinner GBM before any signs of kidney disease, and its effect was dependent on glycemia.
|
31537649 |
2019 |
|
rs1800795
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that IL-6 rs1800795, rs1800796 and rs1800797 played important roles in DN development while IL-6 rs2069837 and rs2069840 might not be related to DN.
|
31451183 |
2019 |
|
rs1800796
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that IL-6 rs1800795, rs1800796 and rs1800797 played important roles in DN development while IL-6 rs2069837 and rs2069840 might not be related to DN.
|
31451183 |
2019 |
|
rs1800797
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that IL-6 rs1800795, rs1800796 and rs1800797 played important roles in DN development while IL-6 rs2069837 and rs2069840 might not be related to DN.
|
31451183 |
2019 |
|
rs2069837
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that IL-6 rs1800795, rs1800796 and rs1800797 played important roles in DN development while IL-6 rs2069837 and rs2069840 might not be related to DN.
|
31451183 |
2019 |
|
rs2069840
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that IL-6 rs1800795, rs1800796 and rs1800797 played important roles in DN development while IL-6 rs2069837 and rs2069840 might not be related to DN.
|
31451183 |
2019 |
|
rs6704078
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, patients with the T allele of rs6704078 had higher STB (13.2 [10.4-17.9] μmol/L versus 11.8 (9.4-14.8) μmol/L; p < 0.001) and similar risks of DR or DKD to those without the T allele.
|
31427625 |
2019 |
|
rs2966449
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of rs2966449 with DKD was also found in the populations older than 70 years, male, not smoking, not drinking, and with duration for T2DM over 20 years.
|
31396261 |
2019 |
|
rs852426
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of rs852426 with DKD sti</span>ll remained statistically significant after Bonferroni correction and particularly significant in the population older than 70 years rather than the 70 years or younger (<i>P</i> = 0.047 for heterogeneity test).
|
31396261 |
2019 |
|
rs34713741
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Comparing three groups, the results were the following: (a) There was a significant difference in the genotype and allele distribution of rs34713741 between DN group and HC group and between T2DM group and DN group; For this gene locus, the risk of diabetic nephropathy in healthy individuals with T allele was 0.6 times higher than that in individuals with GG genotype (OR = 0.60, 95% CI: 0.46 ~ 0.77).
|
31265177 |
2019 |
|
rs11549465
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Recent work has shown that the <i>HIF-1A</i> Pro582Ser polymorphism is more resistant to hyperglycemia-mediated repression, thus protecting against the development of diabetic nephropathy.
|
31214621 |
2019 |
|
rs499765
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, a significant association with estimated glomerular filtration rate (eGFR) was detected: in the non-DKD group, rs838136 was significantly associated with eGFR under an additive model (<i>β</i> = 0.013 ± 0.006, <i>P</i> = 0.0295, <i>β</i> was calculated for log<sub>10</sub>eGFR) as well as a recessive model (<i>P</i> = 0.0385) and rs499765 was associated with eGFR under a dominant model (<i>P</i> = 0.0411) and in the DKD group, rs499765 showed a trend toward association with eGFR under an additive model (<i>β</i> = -0.022 ± 0.012, <i>P</i> = 0.0820, <i>β</i> was calculated for log<sub>10</sub>eGFR) and showed a significant association with eGFR under a dominant model (<i>P</i> = 0.0182).
|
31205953 |
2019 |
|
rs838136
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, a significant association with estimated glomerular filtration rate (eGFR) was detected: in the non-DKD group, rs838136 was significantly associated with eGFR under an additive model (<i>β</i> = 0.013 ± 0.006, <i>P</i> = 0.0295, <i>β</i> was calculated for log<sub>10</sub>eGFR) as well as a recessive model (<i>P</i> = 0.0385) and rs499765 was associated with eGFR under a dominant model (<i>P</i> = 0.0411) and in the DKD group, rs499765 showed a trend toward association with eGFR under an additive model (<i>β</i> = -0.022 ± 0.012, <i>P</i> = 0.0820, <i>β</i> was calculated for log<sub>10</sub>eGFR) and showed a significant association with eGFR under a dominant model (<i>P</i> = 0.0182).
|
31205953 |
2019 |
|
rs17446614
|
|
|
0.020 |
GeneticVariation |
BEFREE |
FOXO1 gene rs17446614 SNP, and the A-C haplotype of rs17446614 and rs17592236 polymorphisms were risk factors for the development of DN.
|
30987438 |
2019 |
|
rs17592236
|
|
|
0.010 |
GeneticVariation |
BEFREE |
FOXO1 gene rs17446614 SNP, and the A-C haplotype of rs17446614 and rs17592236 polymorphisms were risk factors for the development of DN.
|
30987438 |
2019 |
|
rs3765156
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The top significant SNPs from the discovery samples were selected for replication in the independent cohort. rs3765156 in PIK3C2B was significantly associated with DN in the replication cohort after multiple test.
|
30883692 |
2019 |
|
rs4762
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our study indicated that the T174M polymorphism in the AGT gene was associated with DN in Asians.
|
30798724 |
2019 |